section name header

Pronunciation

si-TAL-oh-pram

Classifications

Therapeutic Classification: antidepressants

Pharmacologic Classification: selective serotonin reuptake inhibitors ssris

Indications

BEERS REMS


Unlabeled Use:

Action

  • Selectively inhibits the reuptake of serotonin in the CNS.
Therapeutic effects:
  • Antidepressant action.

Pharmacokinetics

Absorption: 80% absorbed after oral administration.

Distribution: Enters breast milk.

Metabolism/Excretion: Mostly metabolized by the liver (10% by the CYP3A4 and CYP2C19 isoenzymes); the CYP2C19 isoenzyme exhibits genetic polymorphism (2% of Whites, 4% of Blacks, and 14% of Asians may be poor metabolizers and may have significantly citalopram concentrations and an risk of adverse effects). Excreted unchanged in the urine.

Half-Life: 35 hr.

Time/Action Profile

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO1–4 wkunknownunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: QT interval prolongation, postural hypotension, tachycardia, TORSADES DE POINTES

Derm: sweating, photosensitivity, pruritus, rash

EENT: abnormal accommodation

Endo: SIADH

F and E: hyponatremia

GI: salivation, abdominal pain, anorexia, diarrhea, dry mouth, dyspepsia, flatulence, nausea, altered taste, vomiting

GU: libido, amenorrhea, delayed/absent orgasm, dysmenorrhea, ejaculatory delay/failure, erectile dysfunction, polyuria

Hemat: BLEEDING

Metab: appetite, weight gain, weight loss

MS: arthralgia, myalgia

Neuro: apathy, confusion, drowsiness, insomnia, tremor, weakness, libido, depression, agitation, amnesia, anxiety, dizziness, fatigue, impaired concentration, migraine headache, NEUROLEPTIC MALIGNANT SYNDROME, paresthesia, SUICIDAL THOUGHTS

Resp: cough

Misc: fever, SEROTONIN SYNDROME, yawning

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Hepatic Impairment

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

CeleXA

Pill Image

citalopram-_195-9186.jpg
citalopram-_195-9187.jpg

Code

NDC Code