section name header

Pronunciation

ha-loe-PER-i-dole

Classifications

Therapeutic Classification: antipsychotics

Pharmacologic Classification: butyrophenones

Indications

BEERS REMS


Unlabeled Use:
  • Nausea and vomiting from surgery or chemotherapy.

Action

  • Alters the effects of dopamine in the CNS.
  • Also has anticholinergic and alpha-adrenergic blocking activity.
Therapeutic effects:
  • Diminished signs and symptoms of psychoses.
  • Improved behavior in children with Tourette’s syndrome or other behavioral problems.

Pharmacokinetics

Absorption: Well absorbed following PO/IM administration. Decanoate salt is slowly absorbed and has a long duration of action.

Distribution: Concentrates in liver.

Protein Binding: 92%.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: 21–24 hr.

Time/Action Profile

(antipsychotic activity)

ROUTEONSETPEAKDURATION
PO2 hr2–6 hr8–12 hr
IM20–30 min30–45 min4–8 hr
IM (decanoate)3–9 daysunknown1 mo



Effect may persist for several days.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension, QT interval prolongation, tachycardia, TORSADES DE POINTES, ventricular arrhythmias

Derm: diaphoresis, photosensitivity, rash

EENT: blurred vision, dry eyes

Endo: amenorrhea, galactorrhea, gynecomastia

GI: constipation, dry mouth, anorexia, hepatitis, ileus

GU: impotence, urinary retention

Hemat: AGRANULOCYTOSIS, anemia, leukopenia, neutropenia

Metab: weight gain

Neuro: extrapyramidal reactions, confusion, drowsiness, restlessness, SEIZURES, tardive dyskinesia

Resp: respiratory depression

Misc: hypersensitivity reactions, NEUROLEPTIC MALIGNANT SYNDROME

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Haloperidol

Haloperidol Decanoate

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Haldol, Haldol Decanoate

Code

NDC Code