BEERS REMS
Absorption: Well absorbed following PO/IM administration. Decanoate salt is slowly absorbed and has a long duration of action.
Distribution: Concentrates in liver.
Protein Binding: 92%.
Half-Life: 2124 hr.
(antipsychotic activity)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 2 hr | 26 hr | 812 hr |
IM | 2030 min | 3045 min | 48 hr‡ |
IM (decanoate) | 39 days | unknown | 1 mo |
‡Effect may persist for several days.
Contraindicated in:
Use Cautiously in:
CV: hypotension, QT interval prolongation, tachycardia, TORSADES DE POINTES, ventricular arrhythmias
Derm: diaphoresis, photosensitivity, rash
EENT: blurred vision, dry eyes
Endo: amenorrhea, galactorrhea, gynecomastia
GI: constipation, dry mouth, anorexia, hepatitis, ileus
GU: impotence, urinary retention
Hemat: AGRANULOCYTOSIS, anemia, leukopenia, neutropenia
Neuro: extrapyramidal reactions, confusion, drowsiness, restlessness, SEIZURES, tardive dyskinesia
Resp: respiratory depression
Misc: hypersensitivity reactions, NEUROLEPTIC MALIGNANT SYNDROME
Drug-drug:
Drug-Natural Products:
Haloperidol
Haloperidol Decanoate
Lab Test Considerations:
IV Administration:
NDC Code