section name header

Pronunciation

peer-OX-i-kam

Classifications

Therapeutic Classification: antirheumatics, nonopioid analgesics

Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids

Indications

BEERS REMS


Unlabeled Use:

Action

  • Inhibits prostaglandin synthesis.
Therapeutic effects:
  • Suppression of pain and inflammation.

Pharmacokinetics

Absorption: Well absorbed from the GI tract.

Distribution: Unknown. Enters breast milk in small amounts.

Metabolism/Excretion: Mostly metabolized by the liver primarily by the CYP2C9 isoenzyme. Patients who are poor CYP2C9 metabolizers may have reduced metabolism of piroxicam, which may lead to toxicity. Minimal amounts excreted unchanged by the kidneys.

Half-Life: 50 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
PO (analgesic effect)1 hrunknown48–72 hr
PO (anti-inflammatory effect)7–12 days2–3 wkunknown



May take up to 12 wk.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Feldene

Code

NDC Code