Affects the permeability of the fungal cell wall, allowing leakage of cellular contents. Not active against bacteria.
Therapeutic effects:
Inhibited growth and death of susceptible Candida, with decrease in accompanying symptoms of vulvovaginitis (vaginal burning, itching, discharge).
Pharmacokinetics⬆⬇
Absorption: Minimal through intact skin.
Distribution: Unknown. Action is primarily local.
Metabolism/Excretion: Negligible with local application.
Half-Life: Not applicable.
Time/Action Profile⬆⬇
ROUTE
ONSET
PEAK
DURATION
Intravag
unknown
unknown
unknown
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to active ingredients, additives, or preservatives;
OB: /Safety not established.
Use Cautiously in:
Patients with recurrent vulvovaginal yeast infections.
Adv. Reactions/Side Effects⬆⬇
GU: irritation, vulvovaginal burning
Interactions⬆⬇
Drug-drug:
Not known.
Route/Dosage⬆⬇
(Adults and Children ≥12 yr): Vaginal ointment: 1 applicatorful (4.6 g) at bedtime as a single dose.
Availability⬆⬇
Vaginal ointment: 6.5%OTC
Assessment⬆⬇
Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.
Implementation⬆⬇
Consult physician or other health care professional for proper cleansing technique before applying medication.
An applicator is supplied for vaginal administration.
Patient/Family Teaching⬆⬇
Advise patient to avoid using tampons, douches, spermicides, or other vaginal products while using this therapy.
Instruct patient on proper use of vaginal applicator. Medication should be inserted high into the vagina at bedtime. Instruct patient to remain recumbent for at least 30 min after insertion. Advise use of sanitary napkins to prevent staining of clothing or bedding.
Advise patient to consult health care professional regarding intercourse during therapy. Vaginal medication may cause minor skin irritation in sexual partner. Advise patient to refrain from sexual contact during therapy. Advise patient that this medication may weaken latex condoms or diaphragms. Separate use by 3 days. Another method of contraception should be used during treatment.
Advise patient to report to health care professional increased skin irritation or lack of response to therapy. A second course may be necessary if symptoms persist.
Advise patient to dispose of applicator after use.
Evaluation/Desired Outcomes⬆⬇
Decrease in skin irritation and vaginal discomfort. Therapeutic response is usually seen after 1 wk. Diagnosis should be reconfirmed with smears or cultures before a second course of therapy to rule out other pathogens associated with vulvovaginitis. Recurrent vaginal infections may be a sign of systemic illness.
US Brand Names⬆⬇
1–Day, Monistat-1Day, Vagistat-1
Code⬆
NDC Code
0113- L. Perrigo Company
0113-0426- good sense tioconazole 1
0113-0426-54- 1 POUCH in 1 CARTON (0113-0426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
0113- L. Perrigo Company
0113-7426- basic care tioconazole 1
0113-7426-54- 1 POUCH in 1 CARTON (0113-7426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
0363- Walgreen Company
0363-0426- Tioconazole 1
0363-0426-54- 1 POUCH in 1 CARTON (0363-0426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
11673- Target Corporation
11673-426- Up and up tioconazole 1
11673-426-54- 1 POUCH in 1 CARTON (11673-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
11822- Rite Aid Corporation
11822-0426- tioconazole 1 1 dose treatment
11822-0426-1- 1 POUCH in 1 CARTON (11822-0426-1) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
21130- Safeway
21130-060- signature care tioconazole 1
21130-060-54- 1 POUCH in 1 CARTON (21130-060-54) > 1 TUBE, WITH APPLICATOR in 1 POUCH > 4.6 g in 1 TUBE, WITH APPLICATOR
30142- Kroger Company
30142-426- tioconazole 1
30142-426-54- 1 POUCH in 1 CARTON (30142-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
36800- Topco Associates LLC
36800-426- Topcare Tioconazole 1
36800-426-54- 1 POUCH in 1 CARTON (36800-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
37808- H E B
37808-426- Tioconazole 1
37808-426-54- 1 POUCH in 1 CARTON (37808-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
41163- Supervalu Inc
41163-032- Equaline Tioconazole 1
41163-032-54- 1 POUCH in 1 CARTON (41163-032-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
41250- Meijer Distribution Inc
41250-426- tioconazole 1
41250-426-54- 1 POUCH in 1 CARTON (41250-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
41520- American Sales Company
41520-426- CareOne Tioconazole 1
41520-426-54- 1 POUCH in 1 CARTON (41520-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
49035- Wal-Mart Stores Inc
49035-426- Equate tioconazole 1 day
49035-426-54- 1 POUCH in 1 CARTON (49035-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
49348- Strategic Sourcing Services LLC
49348-508- SUNMARK TIOCONAZOLE 1
49348-508-59- 1 APPLICATOR in 1 CARTON (49348-508-59) > 4.6 g in 1 APPLICATOR
49738- Kmart Corporation
49738-088- Smart Sense Tioconazole 1
49738-088-54- 1 POUCH in 1 CARTON (49738-088-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
55312- Western Family Foods Inc
55312-426- Tioconazole 1
55312-426-54- 1 POUCH in 1 CARTON (55312-426-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
55910- Dolgencorp, LLC
55910-731- dg health tioconazole 1
55910-731-54- 1 POUCH in 1 CARTON (55910-731-54) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
59779- CVS Pharmacy
59779-718- tioconazole 1
59779-718-26- 1 POUCH in 1 CARTON (59779-718-26) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
63736- Insight Pharmaceuticals LLC
63736-410- Tioconazole 1 Day
63736-410-01- 1 POUCH in 1 CARTON (63736-410-01) > 1 APPLICATOR in 1 POUCH > 4.6 g in 1 APPLICATOR
63736- Insight Pharmaceuticals LLC
63736-413- MONISTAT TIOCONAZOLE 1
63736-413-01- 1 APPLICATOR in 1 CARTON (63736-413-01) > 4.6 g in 1 APPLICATOR
70000- Cardinal Health
70000-0357- Leader Ticonazole
70000-0357-1- 1 APPLICATOR in 1 CARTON (70000-0357-1) > 4.6 g in 1 APPLICATOR
