kee-toe-PROE-fen
Therapeutic Classification: antipyretics, antirheumatics, nonopioid analgesics
Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids
Absorption: Well absorbed from the GI tract.
Distribution: Unknown.
Protein Binding: 99%.
Half-Life: 2–4 hr.
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO (analgesic) | within 60 min | 1 hr | 4–6 hr |
| PO (anti-inflammatory) | few days–1 wk | unknown | up to 24 hr (SR products) |
Contraindicated in:
Use Cautiously in:
CV: edema, HF, hypertension, MI
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, photosensitivity, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: blurred vision, tinnitus
Endo: gynecomastia
GI: constipation, diarrhea, dyspepsia, nausea, vomiting, anorexia, discomfort, flatulence, GI BLEEDING, HEPATITIS
GU: cystitis, hematuria, renal failure
Hemat: blood dyscrasias, prolonged bleeding time
MS: myalgia
Neuro: drowsiness, headache, dizziness., STROKE, drowsiness, headache, dizziness.
Drug-drug:
Drug-Natural Products:
Lab Test Considerations:
NDC Code