Contraindicated in:
Use Cautiously in:
CV: hypertension, QT interval prolongation.
Derm: alopecia, hypertrichosis.
F and E: hyperkalemia.
GI: diarrhea, abdominal pain, dyspepsia, gingivitis, mouth ulceration.
GU: nephrotoxicity.
Hemat: anemia, pure red cell aplasia.
Metab: anorexia.
Neuro: headache, attention disturbance, delirium, dizziness, fatigue, mental status changes, paresthesia, POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME (PRES), SEIZURES, tremor.
Resp: cough.
Misc: INFECTION , MALIGNANCY (INCLUDING LYMPHOMA AND SKIN CANCER).
Drug-Drug:
Drug-Food:
Renal Impairment
Hepatic Impairment
Absorption: Rapidly absorbed following oral administration; fatty meals reduce rate and extent of absorption.
Distribution: Extensively distributed to extravascular tissues.
Protein Binding: 97%.
Metabolism/Excretion: Primarily metabolized in the liver via the CYP3A4 isoenzyme. Primarily excreted in feces (93%; 5% as unchanged drug), with 2% being excreted in urine.
Half-life: 30 hr.