Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
EENT: red discoloration of tears.
GI: abdominal pain, diarrhea, flatulence, heartburn, nausea, vomiting, HEPATOTOXICITY, red discoloration of saliva and teeth.
GU: red discoloration of urine.
Hemat: bleeding, hemolytic anemia, thrombocytopenia, THROMBOTIC MICROANGIOPATHY (INCLUDING THROMBOTIC THROMBOCYTOPENIC PURPURA AND HEMOLYTIC UREMIA SYNDROME).
MS: arthralgia, muscle weakness, myalgia.
Neuro: ataxia, confusion, drowsiness, fatigue, headache, weakness.
Resp: INTERSTITIAL LUNG DISEASE.
Misc: flu-like syndrome, HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA).
Tuberculosis
- PO, IV (Adults): 600 mg/day or 10 mg/kg/day (up to 600 mg/day) single dose; may also be given twice weekly.
- PO, IV (Children and Infants): 10–20 mg/kg/day single dose or divided every 12 hr (not to exceed 600 mg/day); may also be given twice weekly.
Asymptomatic Carriers of Meningococcus
- PO, IV (Adults): 600 mg every 12 hr for 2 days.
- PO, IV (Children ≥1 mo): 10 mg/kg every 12 hr for 2 days (max: 600 mg/dose).
- PO (Infants <1 mo): 5 mg/kg every 12 hr for 2 days.
H. influenzae Prophylaxis
- PO (Adults): 600 mg/day for 4 days.
- PO (Children): 20 mg/kg/day for 4 days (max: 600 mg/dose).
- PO (Neonates): 10 mg/kg/day for 4 days.
Synergy for S. aureus Infections
- PO (Adults): 300–600 mg twice daily.
- PO (Children and Neonates): 5–20 mg/kg/day divided every 12 hr (max: 600 mg/dose).
Therapeutic Classification: antituberculars
Pharmacologic Classification: rifamycins
Absorption: Well absorbed following oral administration.
Distribution: Widely distributed; enters CSF.
Protein Binding: 80%.
Metabolism/Excretion: Mostly metabolized by the liver; 60% eliminated in feces via biliary elimination.
Half-life: 3 hr.
