- PO (Adults): Hypertension–50 mg once daily initially (range 25–100 mg/day as a single daily dose or 2 divided doses) (initiate therapy at 25 mg once daily in patients who are receiving diuretics or are volume depleted). Prevention of stroke in patients with hypertension and left ventricular hypertrophy: 50 mg once daily initially; hydrochlorothiazide 12.5 mg once daily should be added and/or dose of losartan ↑ to 100 mg once daily followed by an increase in hydrochlorothiazide to 25 mg once daily based on BP response; Nephropathy in patients with type 2 diabetes–50 mg once daily, may ↑ to 100 mg once daily depending on BP response.
- PO (Children ≥ 6 yr): Hypertension–0.7 mg/kg once daily (up to 50 mg/day), may be titrated up to 1.4 mg/kg/day (or 100 mg/day).
Renal Impairment
- (Children ≥6 yr): CCr <30 mL/min: Contraindicated.
Hepatic Impairment
- PO (Adults): Hypertension–25 mg once daily initially; may be ↑ as tolerated.
