SER-tra-leen 
Unlabeled Use:
Contraindicated in:
Use Cautiously in:
CV: QT interval prolongation, chest pain, palpitations, TORSADES DE POINTES.
Derm: ↑ sweating, hot flashes, rash.
EENT: pharyngitis, rhinitis, tinnitus, visual abnormalities.
Endo: SIADH, diabetes.
F and E: ↑ thirst, hyponatremia.
GI: diarrhea, dry mouth, nausea, abdominal pain, altered taste, anorexia, constipation, dyspepsia, flatulence, vomiting.
GU: ↓ libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, menstrual disorders, urinary disorders, urinary frequency.
Hemat: BLEEDING.
Metab: ↑ appetite.
MS: back pain, myalgia.
Neuro: dizziness, drowsiness, fatigue, headache, insomnia, tremor, agitation, anxiety, confusion, emotional lability, hypertonia, hypoesthesia, impaired concentration, manic reaction, nervousness, paresthesia, SUICIDAL THOUGHTS, twitching, weakness, yawning.
Misc: fever.
Drug-Drug:
Drug-Natural Products:
Panic Disorder
Post-Traumatic Stress Disorder
Social Anxiety Disorder
Premenstrual Dysphoric Disorder
Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
Absorption: Appears to be well absorbed after oral administration.
Distribution: Extensively distributed throughout body tissues.
Protein Binding: 98%.
Metabolism/Excretion: Extensively metabolized by the liver; one metabolite has some antidepressant activity; 14% excreted unchanged in feces.
Half-life: 24 hr.
NDC Code*
