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Indications ⬇

BEERS REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: dermal necrosis.

GI: cramps, nausea.

GU: CALCIPHYLAXIS.

Hemat: BLEEDING.

Misc: fever.

Interactions ⬆ ⬇

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

see Calculator

US Brand Names ⬆ ⬇

Coumadin, Jantoven

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: anticoagulants

Pharmacologic Classification: coumarins

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract after oral administration.

Distribution: Minimally distributed to tissues.

Protein Binding: 99%.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP2C9 isoenzyme, with some metabolism via the CYP3A4 isoenzyme; the CYP2C9 isoenzyme exhibits genetic polymorphism (intermediate or poor metabolizers may have significantly ↑ (S)-warfarin concentrations and an ↑ risk of adverse reactions).

Half-life: 42 hr.

Time/Action Profile ⬆ ⬇

(effects on coagulation tests)

ROUTEONSETPEAKDURATION
PO36–72 hr5–7 days†2–5 days‡

†At a constant dose‡After discontinuation

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

WAR-fa-rin audio

Pill Image

warfarinsodium_195_9002.jpg

Code ⬆

NDC Code*