Contraindicated in:
Use Cautiously in:
CV: atrial fibrillation, bradycardia, hypertension, hypotension, peripheral edema.
Derm: rash.
GI: diarrhea, nausea.
Hemat: BLEEDING, leukopenia, THROMBOTIC THROMBOCYTOPENIC PURPURA.
Metab: hyperlipidemia.
MS: back pain, extremity pain, non-cardiac chest pain.
Neuro: dizziness, fatigue, headache.
Resp: cough, dyspnea.
Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA).
Drug-Drug:
Absorption: Well absorbed following oral administration (79%), then rapidly converted to an active metabolite.
Distribution: Unknown.
Protein Binding: Active metabolite: 98%.
Metabolism/Excretion: Active metabolite is metabolized to two inactive compounds; 68% excreted in the urine and 27% in feces as inactive metabolites.
Half-life: Active metabolite: 7 hr (range 2–15 hr).
(effect on platelet function)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | within 1 hr | 2 hr | 5–9 days† |
†Following discontinuation.
NDC Code*