Contraindicated in:
Use Cautiously in:
CV: INTRACRANIAL HEMORRHAGE, fatigue, headache.
GI: HEPATOTOXICITY, abdominal pain, diarrhea, nausea, vomiting.
Derm: rash (↑ in women and peds).
Endo: hyperglycemia.
Metab: ↑cholesterol, ↑ triglycerides.
Misc: allergic reactions, bleeding, fat redistribution, fever, immune reconstitution syndrome.
Drug-Drug:
Drug-Natural Products:
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: >99.9%.
Metabolism/Excretion: Rapidly and extensively metabolized (primarily by CYP3A4), requiring co-administration with ritonavir as a metabolic inhibitor to achieve therapeutic blood levels; eliminated mostly in feces, minimal renal excretion.
Half-life: 5.56 hr.
NDC Code*