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Indications

REMS

Unlabeled Use:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension, QT interval prolongation, arrhythmias, chest pain, hypertension, palpitations, tachycardia.

Derm: rash.

EENT: blurred vision, tinnitus.

GI: dry mouth, constipation, diarrhea, excess salivation, flatulence, nausea, vomiting.

GU: erectile dysfunction, hematuria, priapism, urinary frequency.

Hemat: anemia, leukopenia.

MS: myalgia.

Neuro: drowsiness, confusion, dizziness, dysgeusia, fatigue, hallucinations, headache, insomnia, nightmares, slurred speech, SUICIDAL THOUGHTS, syncope, tremor, weakness.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

Depression

Insomnia

US Brand Names

Desyrel

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antidepressants

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 89–95%.

Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A4 isoenzyme; minimal excretion of unchanged drug by the kidneys.

Half-life: 5–9 hr.

Time/Action Profile

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO1–2 wk2–4 wkwks

Patient/Family Teaching

Pronunciation

TRAZ-oh-done audio

Pill Image

trazodone_hcl_195_9199.jpg

Code

NDC Code*