- IV (Adults and Children >1 mo): 15–18 mg/kg in a single or divided dose, maximum loading dose 20 mg/kg.
- IV (Neonates): 15–20 mg/kg in a single dose. If clinically indicated, ≥15 minutes after completion of the initial loading dose, a 2nd loading dose may be administered over the subsequent 15 minutes as 20 mg/kg for term infants or 10–20 mg/kg for preterm infants.
Maintenance Anticonvulsant
- IV, PO (Adults and Children >12 yr): 1–3 mg/kg/day as a single dose or 2 divided doses.
- IV, PO (Children >5 yr): 2–3 mg/kg/day in 1–2 divided doses.
- IV, PO (Children ≤5 yr): 3–5 mg/kg/day in 1–2 divided doses.
Sedation
- PO, IM (Adults): 30–120 mg/day in 2–3 divided doses. Preoperative sedation: 100–200 mg IM 1–1.5 hr before the procedure.
- PO (Children): 2 mg/kg 3 times daily. Preoperative sedation: 1–3 mg/kg PO/IM/IV 1–1.5 hr before the procedure.
Hypnotic
- PO, SC, IV, IM (Adults): 100–320 mg at bedtime.
- IV, IM, SC (Children): 3–5 mg/kg at bedtime.
Hyperbilirubinemia
- PO (Adults): 90–180 mg/day in 2–3 divided doses.
- PO (Children <12 yr): 3–8 mg/kg/day in 2–3 divided doses, doses up to 12 mg/kg/day have been used.
