Edema
- PO (Adults): 20–80 mg/day as a single dose initially, may repeat in 6–8 hr; may ↑ dose by 20–40 mg every 6–8 hr until desired response. Maintenance doses may be given once or twice daily (doses up to 2.5 g/day have been used in patients with HF or renal disease). Hypertension: 40 mg twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response; Hypercalcemia: 120 mg/day in 1–3 doses.
- PO (Children >1 mo): 2 mg/kg as a single dose; may be ↑ by 1–2 mg/kg every 6–8 hr (maximum dose = 6 mg/kg).
- PO (Neonates): 1–4 mg/kg/dose 1–2 times/day.
- IM, IV (Adults): 20–40 mg, may repeat in 1–2 hr and ↑ by 20 mg every 1–2 hr until response is obtained, maintenance dose may be given every 6–12 hr; Continuous infusion: Bolus 0.1 mg/kg followed by 0.1 mg/kg/hr, double every 2 hr to a maximum of 0.4 mg/kg/hr.
- IM, IV (Children): 1–2 mg/kg/dose every 6–12 hr; Continuous infusion: 0.05 mg/kg/hr, titrate to clinical effect.
- IM, IV (Neonates): 1–2 mg/kg/dose every 12–24 hr.
- SC (Adults): 30 mg over the 1st hr, then 12.5 mg per hr over the next 4 hr with the single-use on-body Infusor. Replace with oral diuretic therapy as soon as possible.
Hypertension
- PO (Adults): 40 mg twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response.
