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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: QT interval prolongation, AORTIC ANEURYSM/DISSECTION, TORSADE DE POINTES.

Derm: photosensitivity, STEVENS-JOHNSON SYNDROME.

Endo: hyperglycemia, hypoglycemia.

GI: diarrhea, nausea, ↑ liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, dyspepsia, vomiting.

MS: arthralgia, myalgia, tendinitis, tendon rupture.

Neuro: agitation, anxiety, confusion, depression, dizziness, ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), hallucinations, headache, insomnia, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS, toxic psychosis, tremor.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS).

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Avelox

Action

Therapeutic Effects:

Spectrum:

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: Fluoroquinolones

Pharmacokinetics

Absorption: Well absorbed (90%) following oral administration.

Distribution: Widely distributed; tissue concentrations may exceed plasma concentrations.

Metabolism/Excretion: Mostly metabolized by the liver; 20% excreted unchanged in urine, 25% excreted unchanged in feces.

Half-life: 12 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POwithin 1 hr1–3 hr24 hr
IVrapidend of infusion24 hr

Patient/Family Teaching

Pronunciation

mox-i-FLOX-a-sin audio

Code

NDC Code*