Drug-Drug:
- ↑risk of elevated liver enzymes when used with bosentan (avoid concurrent use).
- Ingestion of alcohol may result in disulfiram-like reaction.
- Effectiveness may be ↓ by concurrent use of diuretics,corticosteroids, phenothiazines, oral contraceptives, estrogens, thyroid preparations, phenytoin, nicotinic acid, sympathomimetics, rifampin, and isoniazid.
- Alcohol, androgens (testosterone), chloramphenicol, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, fluoroquinolones, MAO inhibitors, NSAIDs (except diclofenac), salicylates , sulfonamides, and warfarin may ↑ the risk of hypoglycemia.
- Concurrent use with warfarin may alter the response to both agents (↑ effects of both initially, then ↓ activity); close monitoring recommended during any changes in dose.
- Beta-adrenergic blockers may mask the signs and symptoms of hypoglycemia.
- May ↑cyclosporine levels.
- Colesevelam may ↓ effects; administer glyburide
4 hr before colesevelam - Topiramate may ↓ levels and ↓ effects
