Treatment of Mild to Moderate Pneumocystis jirovecii Pneumonia
- PO (Adults and Children ≥13 yr): 750 mg twice daily for 21 days.
Prevention of Pneumocystis jirovecii Pneumonia
- PO (Adults and Children ≥13 yr): 1500 mg once daily.
Contraindicated in:
Use Cautiously in:
Drug-Drug:
Drug-Food:
(Generic available)
Treatment of Mild to Moderate Pneumocystis jirovecii Pneumonia
Prevention of Pneumocystis jirovecii Pneumonia
Absorption: Absorption is poor but is increased by food, particularly fat.
Distribution: Enters CSF in very low concentrations (<1% of plasma levels).
Protein Binding: >99.9%.
Metabolism/Excretion: Undergoes enterohepatic recycling; elimination occurs in feces.
Half-life: 2.2–2.9 days.
(plasma concentrations)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | unknown | 1–8 hr; 24–96 hr† | 12 hr |
†Two peaks are due to enterohepatic recycling.
NDC Code*
