section name header

Indications ⬇

BEERS REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension, ECG changes, ARRHYTHMIAS.

Derm: photosensitivity.

EENT: blurred vision, dry eyes.

Endo: gynecomastia.

GI: constipation, dry mouth, nausea, paralytic ileus, unpleasant taste.

GU: urinary retention.

Hemat: blood dyscrasias.

Metab: weight gain.

Neuro: drowsiness, fatigue, lethargy, agitation, confusion, extrapyramidal reactions, hallucinations, headache, insomnia, SUICIDAL THOUGHTS.

Interactions ⬆ ⬇

Drug-Drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Pamelor

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: antidepressants

Pharmacologic Classification: tricyclic antidepressants

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 92%.

Metabolism/Excretion: Mostly metabolized by the liver by the CYP2D6 isoenzyme;the CYP2D6 enzyme system exhibits genetic polymorphism; 7% of population may be poor metabolizers and may have significantly ↑ nortriptyline concentrations and an ↑ risk of adverse effects.

Half-life: 18–28 hr.

Canadian Brand Names ⬆ ⬇

Aventyl

Time/Action Profile ⬆ ⬇

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO2–3 wk6 wkunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

nor-TRIP-ti-leen audio

Code ⬆

NDC Code*