Therapeutic Classification: vasodilators
Pharmacologic Classification:
Absorption: 49% absorbed following oral administration; food delays and ↓ extent of absorption.
Distribution: Highly protein bound.
Protein Binding: 99%.
Metabolism/Excretion: Hydrolyzed by carboxylesterase–1 to form active metabolite which contributes to pharmacologic activity. Also metabolized by CYP3A4 and CYP2C8 to form inactive metabolites. Primarily excreted in feces.
Half-life: 0.8–2.5 hr (selexipag); 6.2–13.5 hr (active metabolite).
3 days are missed, restart at lower dose and titrate. Do not stop selexipag without consulting health care professional.