CNS: intracranial hypertension, dizziness.
EENT: vestibular reactions.
GI: HEPATOTOXICITY, CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea, vomiting, esophagitis, pancreatitis.
Derm: DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS SYNDROME (DRESS), ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, photosensitivity, rash, pigmentation of skin and mucous membranes.
Endo: thyroid disorders.
Hemat: blood dyscrasias.
MS: lupus-like syndrome.
Misc: hypersensitivity reactions, superinfection.
Dynacin, Minocin, Solodyn, Ximino
Therapeutic Classification: anti-infectives
Pharmacologic Classification: tetracyclines
Absorption: Well absorbed from the GI tract. IV administration results in complete bioavailability.
Distribution: Widely distributed, some CSF and good bone penetration; crosses the placenta and enters breast milk.
Metabolism/Excretion: 5–20% excreted unchanged by the urine; some metabolism by the liver with enterohepatic circulation and excretion in bile and feces.
Half-life: 11–26 hr.
8 yr): 4 mg/kg initially, then 2 mg/kg q 12 hr.