Contraindicated in:
Use Cautiously in:
CV: QT INTERVAL SHORTENING, palpitations.
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash.
EENT: diplopia, blurred vision, nystagmus, pharyngitis, vertigo, visual impairment.
F and E: hyperkalemia.
GI: ↑ liver enzymes, abdominal pain, constipation, diarrhea, dry mouth, dysgeusia, dyspepsia, nausea, vomiting.
GU: dysmenorrhea, pain, urinary tract infection.
Metab: ↓ appetite, ↓ weight.
Neuro: dizziness, headache, somnolence, amnesia, aphasia, ataxia, attention disturbance, confusion, disorientation, dysarthria, euphoria, irritability, memory impairment, slowness of thoughts, SUICIDAL THOUGHTS/BEHAVIORS, tremor.
Resp: dyspnea, hiccups.
Misc: fatigue, physical dependence.
Drug-Drug:
Hepatic Impairment
Absorption: Well absorbed (≥88%) following oral administration.
Distribution: Well distributed to extravascular tissues.
Metabolism/Excretion: Primarily metabolized by liver by glucuronidation (via UGT2B7 and UGT2B4) and oxidation (via CYP2E1, CYP2A6, CYP2B6, CYP2C19, and CYP3A4/5). Primarily excreted in urine (88%; <10% as unchanged drug) and feces (5%).
Half-life: 5060 hr.