Contraindicated in:
Use Cautiously in:
Derm: rash, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS).
GI: abdominal pain, diarrhea, nausea.
Misc: fever, hypersensitivity reactions.
Drug-Drug:
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Absorption: Absorption increased with high-fat, high-calorie meal.
Distribution: Primarily distributed into red blood cells.
Protein Binding: 99.8%.
Metabolism/Excretion: Primarily metabolized in liver via the CYP3A4 isoenzyme, with minor metabolism by the CYP2C19, CYP2B6, and CYP2C9 isoenzymes; also undergoes glucuronidation. Primarily excreted in feces (33% as unchanged drug), with 35% excreted in urine (mostly as metabolites).
Half-life: 35.5 hr.
NDC Code*