Contraindicated in:
Use Cautiously in:
CNS: headache.
Derm: palmar-plantar erythrodysesthesia, rash.
EENT: epistaxis.
F and E: hypokalemia, hypomagnesemia, hyponatremia, hypophosphatemia.
GI: diarrhea, hepatotoxicity, abdominal pain, hyperbilirubinemia, nausea, stomatitis, vomiting.
GU: ↑serum creatinine, ↓ fertility.
Hemat: anemia.
MS: arthralgia.
Neuro: peripheral neuropathy.
Misc: fatigue.
Drug-Drug:
Hepatic Impairment
Absorption: High-fat foods increase extent of and delay absorption.
Distribution: Extensively distributed to extravascular tissues.
Metabolism/Excretion: Primarily metabolized by liver via CYP2C8 isoenzyme, and to a lesser extent by CYP3A4. Primarily excreted in feces (86%; 16% as unchanged drug), with 4% being excreted in urine.
Half-life: 8.5 hr.