Contraindicated in:
Use Cautiously in:
Derm: rash (↑ in children).
GI: ↓ appetite, abdominal pain (↑ in children), diarrhea, flatulence, nausea, dyspepsia, vomiting.
Metab: hyperammonemia.
Neuro: fatigue (↑ in adults), headache, neurotoxicity.
Drug-Drug:
Hepatic Impairment
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: PBA: 80.698%.
Metabolism/Excretion: Glycerol phenylbutyrate is a triglyceride prodrug that releases phenylbutyrate (PBA) following the action of lipases in the GI tract. Further metabolism results in conversion to phenylacetate (PAA), the active moiety. PAA binds glutamine in the liver and kidneys forming phenylacetylglutamine (PAGN), which is then renally eliminated (68.9%). Women form a higher percentage of metabolites.
Half-life: Unknown.
NDC Code*