Ulcerative Colitis
- PO (Adults): 1 g every 6–8 hr (may start with 500 mg every 6–12 hr), followed by maintenance dose of 500 mg every 6 hr.
- PO (Children >2 yr): Initial: 6.7–10 mg/kg every 4 hr or 10–15 mg/kg every 6 hr or 13.3–20 mg/kg every 8 hr. Maintenance: 7.5 mg/kg every 6 hr (not to exceed 2 g/day).
Rheumatoid Arthritis
- PO (Adults): 500 mg–1 g/day (as delayed-release tablets) for 1 wk, then ↑ by 500 mg/day every wk up to 2 g/day in 2 divided doses; if no benefit seen after 12 wk, ↑ to 3 g/day in 2 divided doses.
- PO (Children ≥6 yr): 30–50 mg/kg/day in 2 divided doses (as delayed-release tablets); initiate therapy at 25% of planned maintenance dose and ↑ every 7 days until maintenance dose is reached (not to exceed 2 g/day).
