IV, Infiltration:
Local:
Unlabeled Use:
Contraindicated in:
Use Cautiously in:
With IV use
CNS: CEREBROVASCULAR SPASM, dizziness, weakness.
EENT: nasal stuffiness.
CV: hypotension, MI, angina, arrhythmias, tachycardia.
GI: abdominal pain, diarrhea, nausea, vomiting, aggravation of peptic ulcer.
Derm: flushing.
Local: injection site pain (local).
Drug-Drug:
(Generic available)
Hypertension Associated with Pheochromocytoma Before/During Surgery
Prevention of Dermal Necrosis during Infusion of Norepinephrine, Phenylephrine, or Dopamine
Treatment of Dermal Necrosis Following Extravasation of Norepinephrine, Phenylephrine, or Dopamine
Reversal of Intraoral Submucosal Anesthesia Following Dental Procedures (Oraverse)
Therapeutic Classification: agents for pheochromocytoma
Pharmacologic Classification: alpha adrenergic blockers
Absorption: Well absorbed following IM administration; completely available after local injection.
Distribution: Unknown.
Metabolism/Excretion: 10% excreted unchanged by kidneys.
Half-life: 19 min (IV); 23 hr (local injection).
(alpha-adrenergic blockade)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
IM | unknown | 20 min | 3045 min |
IV | immediate | 2 min | 1530 min |
Local | rapid | 1020 min | unknown |
NDC Code*