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Indications

High Alert

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: NEUROLEPTIC MALIGNANT SYNDROME, confusion, disorientation, sedation, dizziness, extrapyramidal reactions, fatigue, insomnia, nervousness.

EENT: blurred vision, diplopia, tinnitus.

CV: bradycardia, hypertension, hypotension, tachycardia.

GI: constipation, drug-induced hepatitis, dry mouth.

Derm: photosensitivity, severe tissue necrosis upon infiltration at IV site, rashes.

Hemat: blood dyscrasias.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Antihistamine

Antivertigo (Motion Sickness)

Sedation

Sedation during Labor

Antiemetic

US Brand Names

Phenergan

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiemetics, antihistamines, sedative/hypnotics

Pharmacologic Classification: phenothiazines

Pharmacokinetics

Absorption: Well absorbed after oral (88%) and IM administration; rectal administration may be less reliable.

Distribution: Widely distributed; crosses the blood-brain barrier and the placenta.

Protein Binding: 65–90%.

Metabolism/Excretion: Metabolized by the liver.

Half-life: 9–16 hr.

Canadian Brand Names

Histantil

Time/Action Profile

(noted as antihistaminic effects; sedative effects last 2–8 hr)

ROUTEONSETPEAKDURATION
PO, IM20 minunknown4–12 hr
Rectal20 minunknown4–12 hr
IV3–5 minunknown4–12 hr

Patient/Family Teaching

Pronunciation

proe-METH-a-zeen audio

Code

NDC Code*