Contraindicated in:
Use Cautiously in:
GI: abdominal pain, diarrhea, gastroenteritis, GI PERFORATION, nausea, vomiting.
Misc: opioid withdrawal.
Drug-Drug:
Drug-Natural Products:
Absorption: Rapidly absorbed; absorption delayed by high-fat meal by 2 hr.
Distribution: Moderate tissue distribution, does not cross the blood-brain barrier.
Protein Binding: 9394%.
Metabolism/Excretion: Primarily metabolized by liver via the CYP3A isoenzyme to an active metabolite (nor-naldemedine); 57% excreted in urine (1618% as unchanged drug), 35% excreted in feces.
Half-life: 11 hr.
NDC Code*