CV: palpitations, tachycardia, cardiomyopathy (↑ with prolonged use or high doses), hypertension, hypotension, peripheral vasculopathy, SUDDEN DEATH.
Derm: alopecia, urticaria.
EENT: blurred vision, mydriasis.
Endo: growth inhibition (with long term use in children).
GI: anorexia, constipation, cramps, diarrhea, dry mouth, intestinal ischemia, nausea, vomiting.
GU: libido changes, erectile dysfunction, priapism.
MS: RHABDOMYOLYSIS.
Neuro: hyperactivity, insomnia, restlessness, tremor, aggression, anger, behavioral disturbances, dizziness, dysgeusia, hallucinations, headache, irritability, mania, paresthesia, skin picking, talkativeness, thought disorder, tics.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), psychological dependence.
(Generic available)
Amount is expressed in total amphetamine content (amphetamine + dextroamphetamine)
- Immediate-release tablets: 5 mg; 7.5 mg; 10 mg; 12.5 mg; 15 mg; 20 mg; 30 mg;
- Extended-release capsules (Adderall XR): 5 mg; 10 mg; 15 mg; 20 mg; 25 mg; 30 mg;
- Extended-release capsules (Mydayis): 12.5 mg; 25 mg; 37.5 mg; 50 mg;
Dose is expressed in total amphetamine content (amphetamine + dextroamphetamine)
Attention-Deficit/Hyperactivity Disorder
- PO (Adults): Immediate-release tablets: 5 mg 1–2 times daily; may ↑ daily dose in 5–mg increments at weekly intervals; usual dose range = 5–40 mg/day in 1–3 divided doses. Extended-release capsules (Adderall XR): 20 mg once daily; Extended-release capsules (Mydayis): 12.5–25 mg once daily in the morning upon awakening; may ↑ daily dose in 12.5–mg increments at weekly intervals. (maximum dose = 50 mg/day).
- PO (Children ≥13 yr): Immediate-release tablets: 5 mg 1–2 times daily; may ↑ daily dose in 5–mg increments at weekly intervals; usual dose range = 5–40 mg/day in 1–3 divided doses. Extended-release capsules (Adderall XR): 10 mg once daily in the morning; may ↑ to 20 mg once daily in the morning after 1 wk; Extended-release capsules (Mydayis): 12.5 mg once daily in the morning upon awakening; may ↑ daily dose in 12.5–mg increments at weekly intervals (maximum dose = 25 mg/day).
- PO (Children 6–12 yr): Immediate-release tablets: 5 mg 1–2 times daily; may ↑ daily dose in 5–mg increments at weekly intervals; usual dose range = 5–40 mg/day in 1–3 divided doses. Extended-release capsules (Adderall XR): 5–10 mg once daily in the morning; may ↑ daily dose in 5–10–mg increments at weekly intervals (maximum dose = 30 mg/day).
- PO (Children 3–5 yr): Immediate-release tablets: 2.5 mg once daily in the morning; may ↑ daily dose in 2.5–mg increments at weekly intervals; usual dose range = 2.5–40 mg/day in 1–3 divided doses.
Renal Impairment
- PO (Adults): GFR 15–29 mL/min/1.73 m2: Extended-release capsules (Adderall XR)—15 mg once daily in the morning; Extended–release capsules (Mydayis)—12.5 mg once daily in the morning upon awakening; may ↑ daily dose in 12.5–mg increments at weekly intervals (maximum dose = 25 mg/day).
Renal Impairment
- (Children ≥13 yr): GFR 15–29 mL/min/1.73 m2: Extended–release capsules (Mydayis)—12.5 mg once daily in the morning upon awakening (maximum dose = 12.5 mg/day).
Renal Impairment
- (Children ≥6 yr): GFR 15–29 mL/min/1.73 m2: Extended–release capsules (Adderall XR)—5 mg once daily in the morning (maximum dose = 20 mg/day in children 6–12 yrs).
Narcolepsy
- PO (Adults and Children ≥13 yr): Immediate-release tablets: 10 mg once daily in the morning; may ↑ daily dose in 10–mg increments at weekly intervals; usual dosage range = 5–60 mg/day in 1–3 divided doses.
- PO (Children 6–12 yr): Immediate-release tablets: 5 mg once daily; may ↑ daily dose in 5–mg increments at weekly intervals; usual dose range = 5–60 mg/day in 1–3 divided doses.
Adderall, Adderall XR, Mydayis
Therapeutic Classification: central nervous system stimulants
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed in body tissues, with high concentrations in the brain and CSF.
Metabolism/Excretion: Some metabolism by the liver. Urinary excretion is pH-dependent. Alkaline urine promotes reabsorption and prolongs action.
Half-life: Children 6–12 yrs: 9–11 hr; Adults: 10–13 hr (depends on urine pH).
