ris-ED-roe-nate 
Contraindicated in:
Use Cautiously in:
CV: chest pain, edema.
Derm: rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
EENT: amblyopia, conjunctivitis, dry eyes, eye pain/inflammation, tinnitus.
GI: abdominal pain, diarrhea, belching, colitis, constipation, dysphagia, esophageal cancer, esophageal ulcer, esophagitis, gastric ulcer, nausea.
MS: arthralgia, musculoskeletal pain, femur fractures, osteonecrosis (primarily of jaw).
Neuro: weakness.
Resp: asthma exacerbation.
Misc: flu-like syndrome.
Drug-Drug:
Drug-Food:
(Generic available)
Prevention and Treatment of Postmenopausal Osteoporosis
Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Treatment of Osteoporosis in Men
Treatment of Paget's Disease
Absorption: Rapidly but poorly absorbed following oral administration (0.63% bioavailability).
Distribution: 60% of absorbed dose distributes to bone.
Metabolism/Excretion: 40% of absorbed dose is excreted unchanged by kidneys; unabsorbed drug is excreted in feces.
Half-life: Initial: 1.5 hr; terminal: 220 hr (reflects dissociation from bone).
NDC Code*