• Moderately to severely active rheumatoid arthritis in patients who have had an inadequate response/intolerance to ≥1 tumor necrosis factor (TNF) blocker (not to be used with other Janus kinase [JAK] inhibitors, biologic disease modifying antirheumatic drugs [DMARDs] or potent immunosuppressants [including azathioprine or cyclosporine]).
• Active psoriatic arthritis in patients who have had an inadequate response/intolerance to ≥1 TNF blocker (not to be used with other JAK inhibitors, biologic DMARDs or potent immunosuppressants [including azathioprine or cyclosporine]).
• Refractory, moderate to severe atopic dermatitis in patients whose disease is not adequately controlled with other systemic drug products, including biologics, or when use of those therapies are not recommended (not to be used with other JAK inhibitors, biologic immunomodulators, or other immunosuppressants.
• Moderately to severely active ulcerative colitis in patients who have had an inadequate response/intolerance to ≥1 TNF blocker (not to be used with other JAK inhibitors, biological therapies, or potent immunosuppressants [including azathioprine or cyclosporine]).
• Moderately to severely active Crohn's disease in patients who have had an inadequate response/intolerance to ≥1 TNF blocker (not to be used with other JAK inhibitors, biological therapies, or potent immunosuppressants [including azathioprine or cyclosporine]).
• Active ankylosing spondylitis in patients who have had an inadequate response/intolerance to ≥1 TNF blocker (not to be used with other JAK inhibitors, biologic DMARDs, or potent immunosuppressants [including azathioprine or cyclosporine]).
• Active non-radiographic axial spondyloarthritis in patients with objective signs of inflammation who have had an inadequate response or intolerance to TNF blocker therapy (not to be used with other JAK inhibitors, biologic DMARDs, or potent immunosuppressants [including azathioprine or cyclosporine]).

Contraindicated in:

• Hypersensitivity
• Active infection
• Lymphocyte count <500 cells/mm³, absolute neutrophil count (ANC) <1000 cells/mm³, or Hgb <8 g/dL
• Increased risk for thrombosis
• History of MI or stroke
• Severe hepatic impairment
• End-stage renal disease (CCr <15 mL/min) (atopic dermatitis and ulcerative colitis only)
• OB: Pregnancy
• Lactation: Lactation.

Use Cautiously in:

• Patients who are >50 yr old and have ≥1 cardiovascular risk factor (↑ risk of all-cause mortality, cardiovascular death, MI, stroke, and thrombosis)
• Current or past history of smoking (↑ risk of malignancy, cardiovascular death, MI, or stroke)
• Known malignancy
• Previously exposed to tuberculosis (TB)
• History of serious or opportunistic infection
• Resided or traveled in areas of endemic TB or endemic mycoses
• Underlying conditions that predispose to infection
• History of diverticulitis or use of NSAIDs (↑ risk of GI perforation)
• End-stage renal disease
• Rep: Women of reproductive potential
• Pedi: Safety and effectiveness not established in children <18 yr (rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis) or <12 yr (atopic dermatitis).

CV: MI, ARTERIAL THROMBOSIS, CARDIOVASCULAR DEATH, DEEP VEIN THROMBOSIS.

GI: ↑ liver enzymes, GI PERFORATION, nausea.

Hemat: anemia, lymphopenia, NEUTROPENIA.

Metab: dyslipidemia.

MS: ↑ creatine kinase.

Neuro: STROKE.

Resp: cough, PULMONARY EMBOLISM.

Misc: DEATH, fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), INFECTION (INCLUDING TB, BACTERIAL, INVASIVE FUNGAL, VIRAL, OR OPPORTUNISTIC INFECTIONS), MALIGNANCY.

Drug-Drug:

• May ↑ risk of adverse reactions and ↓ antibody response to live vaccines; avoid concurrent use.
• Strong CYP3A4 inhibitors, including ketoconazole or clarithromycin, may ↑ levels and the risk of toxicity; avoid concurrent use.
• Strong CYP3A4 inducers, including rifampin, may ↓ levels and effectiveness; concurrent use not recommended.
• NSAIDs may ↑ risk of GI perforation; concurrent use requires careful monitoring.
• ↑ risk of immunosuppression when used concurrently with other potent immunosuppressants including azathioprine, cyclosporine, tacrolimus, antineoplastics, or radiation therapy.

Drug-Food:

• Grapefruit or grapefruit juice may ↑ levels and the risk of toxicity; avoid concurrent use.

• Extended-release tablets: 15 mg; 30 mg; 45 mg;

Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, or Non-Radiographic Axial Spondyloarthritis

• PO (Adults): 15 mg once daily.

Atopic Dermatitis

• PO (Geriatric Patients ≥65 yr): 15 mg once daily.
• PO (Adults and Children 12–64 and ≥40 kg): 15 mg once daily. If adequate response not achieved, may ↑ to 30 mg once daily. If adequate response not achieved with 30 mg once daily, discontinue therapy. Concurrent use of strong CYP3A4 inhibitors: 15 mg once daily.

Ulcerative Colitis

• PO (Adults): Induction therapy: 45 mg once daily for 8 wk. Maintenance therapy: 15 mg once daily; may ↑ to 30 mg once daily if patients have refractory, severe, or extensive disease. If adequate response not achieved with 30 mg once daily, discontinue therapy. Concurrent use of strong CYP3A4 inhibitors: ↓ induction therapy dose to 30 mg once daily for 8 wk. For maintenance therapy, do not exceed 15 mg once daily.

Crohn's Disease

• PO (Adults): Induction therapy: 45 mg once daily for 12 wk. Maintenance therapy: 15 mg once daily; may ↑ to 30 mg once daily if patients have refractory, severe, or extensive disease. If adequate response not achieved with 30 mg once daily, discontinue therapy. Concurrent use of strong CYP3A4 inhibitors: ↓ induction therapy dose to 30 mg once daily for 12 wk. For maintenance therapy, do not exceed 15 mg once daily.

Rinvoq

• Inhibits JAK enzymes, which prevents the activation of signal transducers, and activators of transcription, which ultimately results in decreased hematopoiesis and immune cell function.

• Improvement in clinical and symptomatic parameters of rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and non-radiographic axial spondyloarthritis.

Therapeutic Classification: antirheumatics

Pharmacologic Classification: kinase inhibitors

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP3A4 isoenzyme and to a lesser extent by the CYP2D6 isoenzyme; 38% excreted in feces and 24% excreted in urine as unchanged drug.

Half-life: 8–14 hr.

(clinical improvement)

• Instruct patient to take upadacitinib as directed. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
• Caution patient to avoid grapefruit or grapefruit juice during therapy.
• Advise patient to avoid live vaccines during therapy.
• Caution patient to notify health care professional immediately if signs of infection (fever, sweating, chills, muscle aches, cough, shortness of breath, blood in phlegm, weight loss, warm, red, or painful skin or sores, diarrhea or stomach pain, burning on urination or urinating more often than normal, feeling very tired), blood clots, or stomach or intestinal perforation (fever, stomach-area pain that does not go away, change in bowel habits) occur.
• Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
• Instruct patient to notify health care professional of medication regimen prior to treatment or surgery.
• Inform patient of increased risk of lymphoma and other cancers. Advise patient to have periodic skin exams for new lesions of skin cancer.
• Instruct patients to contact their health care professional if medication residue is observed repeatedly in stool or ostomy output.
• Rep: May cause fetal harm. Advise females of reproductive potential to use effective contraception during and for 4 wk after final dose and to avoid breastfeeding during and for 6 days after last dose. Advise patient to notify health care professional immediately if pregnancy is planned or suspected. If pregnancy occurs during therapy report to the AbbVie Inc.’s Adverse Event reporting line at 1-800-633-9110, or FDA at 1-800-FDA-1088 or medwatch.
• Emphasize the importance of regular lab tests to monitor for adverse drug reactions.

ue-PAD-a-sye-ti-nib

NDC Code^*

• 0074- AbbVie Inc.
  • 0074-2306- Rinvoq
    • 0074-2306-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (0074-2306-30)

• 0074- AbbVie Inc.
  • 0074-2306- Rinvoq
    • 0074-2306-70- 14 TABLET, EXTENDED RELEASE in 1 BOTTLE (0074-2306-70)