• Inflammatory disorders including:
  • Rheumatoid arthritis,
  • Osteoarthritis.
• Mild to moderate pain.
• Fever.

Contraindicated in:

• Hypersensitivity to aspirin or other salicylates
• Cross-sensitivity with other NSAIDs may exist (less with nonaspirin salicylates)
• Children or adolescents with viral infections (may increase the risk of Reye’s syndrome).

Use Cautiously in:

• History of GI bleeding or ulcer disease
• Chronic alcohol use/abuse
• Severe renal disease (magnesium toxicity may occur)
• Severe hepatic disease
• Geriatric patients (↑ risk of adverse reactions especially GI bleeding; more sensitive to toxic levels)
• OB: Salicylates may have adverse effects on fetus and mother and in general should be avoided during pregnancy, especially during the 3rd trimester
• Lactation: Safety not established.

EENT: tinnitus.

GI: GI BLEEDING, dyspepsia, epigastric distress, nausea, abdominal pain, anorexia, hepatotoxicity, vomiting.

Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS AND LARYNGEAL EDEMA.

Drug-Drug:

• May ↑ activity of penicillins, phenytoin, methotrexate, valproic acid, oral hypoglycemic agents, and sulfonamides.
• May ↓ beneficial effects of probenecid.
• Urinary acidification↑ reabsorption and may ↑ serum salicylate levels.
• Alkalinization of the urine or the ingestion of large amounts of antacids ↑excretion and ↓ serum salicylate levels.
• May blunt the therapeutic response to diuretics or other antihypertensives.
• ↑risk of GI irritation with NSAIDs.

Drug-Food:

• Foods capable of acidifying the urine (see Appendix M) may ↑ serum salicylate levels.

• Tablets: 304 mg^OTC; 467 mg^OTC; 545 mg; 600 mg; 650 mg;

• PO (Adults): 304 mg q 4 hr or 467 mg q 6 hr.

Doan’s Regular Strength Tablets, Magan, Mobidin

• Produce analgesia and reduce inflammation and fever by inhibiting the production of prostaglandins.

• Analgesia.
• Reduction of inflammation.
• Reduction of fever.

Therapeutic Classification: antipyretics, nonopioid analgesics

Pharmacologic Classification: salicylates

Absorption: Well absorbed after oral administration.

Distribution: Rapidly and widely distributed; crosses the placenta and enter breast milk.

Metabolism/Excretion: Extensively metabolized by the liver; inactive metabolites excreted by the kidneys. Amount excreted unchanged by the kidneys depends on urine pH; as pH increases, amount excreted unchanged increases from 2–3% up to 80%.

Half-life: 2–3 hr for low doses; up to 15–30 hr with larger doses because of saturation of liver metabolism.

Doan’s Backache Pills

• Instruct patient to take salicylates with a full glass of water and to remain in an upright position for 15–30 min after administration.
  • Advise patient to report tinnitus; unusual bleeding of gums; bruising; black, tarry stools; or fever lasting longer than 3 days.
  • Caution patient to avoid concurrent use of alcohol with this medication to minimize possible gastric irritation; 3 or more glasses of alcohol per day may increase the risk of GI bleeding. Caution patient to avoid taking concurrently with acetaminophen or NSAIDs for more than a few days, unless directed by health care professional to prevent analgesic nephropathy.
  • Teach patients on a sodium-restricted diet to avoid effervescent tablets or buffered-aspirin preparations.
  • Tablets with an acetic (vinegar-like) odor should be discarded.
  • Advise patients on long-term therapy to inform health care professional of medication regimen before surgery. Salicylates may need to be withheld for 1 wk before surgery.

mag-NEE-zhum sal-I-sil-ate

NDC Code^*

• 15127- Land R Distributors, Inc.
  • 15127-448- Backache Aid
    • 15127-448-24- 3 BLISTER PACK in 1 CARTON (15127-448-24) > 8 TABLET, FILM COATED in 1 BLISTER PACK

• 55741- Dr. Reddy's Laboratories Inc.
  • 55741-224- Doans Extra Strength
    • 55741-224-24- 1 BOTTLE in 1 BOX (55741-224-24) > 24 TABLET in 1 BOTTLE

• 59779- CVS Pharmacy
  • 59779-338- Backache Relief
    • 59779-338-08- 3 BLISTER PACK in 1 CARTON (59779-338-08) > 8 TABLET, FILM COATED in 1 BLISTER PACK

• 63029- Medtech Products Inc.
  • 63029-051- Percogesic
    • 63029-051-48- 1 BOTTLE in 1 CARTON (63029-051-48) > 48 TABLET, COATED in 1 BOTTLE