Anti-inflammatory
- PO (Adults): Arthritis (immediate–release)25–50 mg 2–4 times daily (max dose = 200 mg/day). A single bedtime dose of 100 mg may alternatively be used; Arthritis (extended–release) 75 mg once or twice daily (max dose = 150 mg/day). Gout: 100 mg initially, followed by 50 mg 3 times daily for relief of pain, then ↓ further.
- PO (Children >2 yr): 1–2 mg/kg/day in 2–4 divided doses (not to exceed 4 mg/kg/day or 150–200 mg/day).
PDA Closure
- IV (Neonates): Treatment: 0.2 mg/kg initially, then 2 subsequent doses at 12–24 hr intervals of 0.1 mg/kg if age <48 hr at time of initial dose; 0.2 mg/kg if 2–7 days at initial dose; 0.25 mg/kg if age >7 days at initial dose. Prophylaxis: 0.1–0.2 mg/kg initially, then 0.1 mg/kg every 12–24 hr for 2 doses.