CV: edema, hypotension.
EENT: pharyngitis, rhinitis, sinusitis.
F and E: hyperkalemia.
GI: abdominal pain, diarrhea, nausea.
GU: impaired renal function.
MS: arthralgia, back pain.
Neuro: dizziness, fatigue, headache.
Misc: ANGIOEDEMA.
Hypertension
- PO (Adults): 80 mg or 160 mg once daily when used as monotherapy in patients who are not volume depleted; may be ↑ up to 320 mg once daily.
- PO (Children 6–16 yr): 1.3 mg/kg once daily (maximum dose = 40 mg/day); may ↑ up to 2.7 mg/kg once daily (maximum dose = 160 mg/day).
Heart Failure
- PO (Adults): 40 mg twice daily, dose may be titrated up to target dose of 160 mg twice daily, as tolerated.
Post-Myocardial Infarction
- PO (Adults): 20 mg twice daily (may be initiated
12 hours after MI), dose may be titrated up to target dose of 160 mg twice daily, as tolerated.
Therapeutic Classification: antihypertensives
Pharmacologic Classification: angiotensin II receptor antagonists
Absorption: 10–35% absorbed following oral administration.
Distribution: Crosses the placenta.
Protein Binding: 95%.
Metabolism/Excretion: Minor metabolism by the liver; 13% excreted in urine; 83% in feces.
Half-life: 6 hr.
(antihypertensive effect)
*After single dose.
†Chronic dosing.
