Contraindicated in:
Use Cautiously in:
Derm: rash.
EENT: nasopharyngitis, sinus congestion.
GI: abdominal pain, diarrhea, dry mouth.
MS: muscle twitching, myalgia.
Neuro: dizziness, sedation, anxiety, confusion, fatigue, gait disturbances, memory impairment, SUICIDAL THOUGHTS/BEHAVIORS, tremor.
Misc: physical dependence.
Drug-Drug:
Renal Impairment
Hepatic Impairment
Absorption: Extent of absorption following oral administration unknown. Absorption increased with fat-containing foods.
Distribution: Extensively distributed to tissues.
Metabolism/Excretion: Extensively metabolized in the liver via the CYP3A4 isoenzyme to inactive metabolites. 45% excreted in urine and 41% excreted in feces primarily as metabolites.
Half-life: 19.724.6 hr.