Contraindicated in:
Use Cautiously in:
CV: QT interval prolongation.
Derm: rash.
Endo: Graves' disease, hyperglycemia.
GI: nausea, ↑ lipase, ↑ liver enzymes, abdominal pain, autoimmune hepatitis, diarrhea, dyspepsia, hyperbilirubinemia, vomiting.
GU: ↑ serum creatinine.
Hemat: anemia, neutropenia.
Metab: hypercholesterolemia, hyperuricemia.
MS: ↑ creatine kinase, polymyositis.
Neuro: Guillain-Barré syndrome, headache, insomnia, sedation.
Misc: fatigue, immune reconstitution syndrome.
Drug-Drug:
Drug-Natural Products:
Absorption: 27% of temsavir absorbed following oral administration; absorption ↑ with high-fat meal.
Distribution: Moderately distributed to extravascular tissues.
Metabolism/Excretion: Fostemsavir is a prodrug that is hydrolyzed to the active form, temsavir. Temsavir undergoes metabolism to inactive metabolites through the liver via hydrolysis and oxidation (via the CYP3A4 isoenzyme). Primarily excreted in urine (51%, <2% as unchanged drug), with 33% excreted in feces (1% as unchanged drug).
Half-life: 11 hr.