Prevention of Nausea and Vomiting Due to Emetogenic Chemotherapy
- PO (Adults): 1 mg twice daily; 1st dose given at least 60 min prior to chemotherapy and 2nd dose 12 hr later only on days when chemotherapy is administered; may also be given as 2 mg once daily at least 60 min prior to chemotherapy.
- IV (Adults and Children 2–16 yr): 10 mcg/kg given within 30 min prior to chemotherapy or 20–40 mcg/kg/day divided once or twice daily (maximum: 3 mg/dose or 9 mg/day).
- Transdermal (Adults): One patch applied up to 48 hr prior to chemotherapy, leave in place for at least 24 hr following chemotherapy, may be left in place for a total of 7 days.
Prevention of Nausea and Vomiting Associated with Radiation Therapy
- PO (Adults): 2 mg taken once daily within 1 hr of radiation therapy.
Prevention and Treatment of Postoperative Nausea and Vomiting
- IV (Adults): Prevention: 1 mg prior to induction of anesthesia or just prior to reversal of anesthesia; Treatment: 1 mg.
- IV (Children ≥4 yr): 20–40 mcg/kg as a single dose (maximum: 1 mg).
Prevention of Acute and Delayed Nausea and Vomiting Due to Emetogenic Chemotherapy
- SC (Adults): 10 mg given at least 30 min prior to chemotherapy (with dexamethasone) on Day 1 of chemotherapy; do not administer more frequently than every 7 days.
Renal Impairment
- SC (Adults): CCr 30–59 mL/min: Do not administer more frequently than every 14 days.
