SAL-sa-late 
Contraindicated in:
Use Cautiously in:
EENT: tinnitus.
GI: GI BLEEDING, dyspepsia, epigastric distress, nausea, abdominal pain, anorexia, hepatotoxicity, vomiting.
Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS AND LARYNGEAL EDEMA.
Drug-Drug:
Drug-Food:
Therapeutic Classification: antipyretics, nonopioid analgesics
Pharmacologic Classification: salicylates
Absorption: Splits into 2 molecules of salicylic acid after oral administration; absorbed in the small intestine.
Distribution: rapidly and widely distributed; cross the placenta and enter breast milk.
Metabolism/Excretion: Extensively metabolized by the liver; inactive metabolites excreted by the kidneys. Amount excreted unchanged by the kidneys depends on urine pH; as pH increases, amount excreted unchanged increases from 2–3% up to 80%.
Half-life: 2–3 hr for low doses; up to 15–30 hr with larger doses because of saturation of liver metabolism.
NDC Code*