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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, urticaria

Endo: gynecomastia

GU: ↓libido, ejaculation disorders, erectile dysfunction, PROSTATE CANCER (HIGH-GRADE), testicular pain, testicular swelling

Neuro: depression

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Avodart

Action ⬆ ⬇

  • Inhibits the enzyme 5-alpha-reductase, which is responsible for converting testosterone to its potent metabolite 5-alpha-dihydrotestosterone in the prostate gland and other tissues. 5-Alpha-dihydrotestosterone is partly responsible for prostatic hyperplasia.
Therapeutic effects:
  • Reduced prostate size with associated decrease in urinary symptoms.

Classifications ⬆ ⬇

Therapeutic Classification: benign prostatic hyperplasia bph agents

Pharmacologic Classification: androgen inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (60%) following oral administration; also absorbed through skin.

Distribution: 11.5% of serum concentration partitions into semen.

Protein Binding: 99% bound to albumin; 96.6% bound to alpha-1 glycoprotein.

Metabolism/Excretion: Mostly metabolized by the liver via the CYP3A4 isoenzyme; metabolites are excreted in feces.

Half-Life: 5 wk.

Time/Action Profile ⬆ ⬇

(↓ in dihydrotestosterone levels‡)
ROUTEONSETPEAKDURATION
POunknown1–2 wkunknown

‡Symptoms may only improve over 3–12 mo.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

doo-TAS-te-ride

Code ⬆

NDC Code