Contraindicated in:
Use Cautiously in:
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
GI: ↑liver enzymes, nausea.
MS: arthralgia, gout flare.
Drug-Drug:
Renal Impairment
Therapeutic Classification: antigout agents
Pharmacologic Classification: xanthine oxidase inhibitors
Absorption: Well absorbed (49%) following oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: 99.2%.
Metabolism/Excretion: Extensively metabolized by the liver; minimal renal excretion of unchanged drug, 45% eliminated in feces as unchanged drug, remainder is eliminated in urine and feces as inactive metabolites.
Half-life: 5–8 hr.
NDC Code*