Kwashiorkor

• IM (Children): 30 mg followed by oral dosing.
• PO (Adults and Children >8 yr): 10,000–20,000/day for at least 2 mo.
• PO (Children <8 yr): 5,000–10,000/day for at least 2 mo.

Xerophthalmia

• PO, IM (Children): 110 mg/day PO as retinyl palmitate or 55 mg IM then 110 mg PO/day given with vitamin E to improve effectiveness.

Parenteral dosing

• IM (Adults): 1000,000 units/day for 3 days, then 50,000 units/day for 2 wk with additional followup oral therapy of 10,000–20,000 units/day.
• IM (Children 1–8 yr): 17,500–35,000 units/day for 10 days with additional followup oral therapy of 5000–10,000 units/day.
• IM (Infants): 7500–15,000 units/day with additional followup oral therapy of 5000–10,000 units/day.
• IV (Adults and Children): Infused as part of TPN in amounts required to meet nutritional needs (in parenteral multivitamin preparations).

Aquasol A

• Serves as a cofactor in many biochemical processes.
• Necessary for growth, bone development, vision, reproduction, integrity of mucosal and epithelial surfaces, and formation of visual pigment.

• Resolution of deficiency signs.
• Prevention of deficiency.

Therapeutic Classification: vitamins (fat-soluble)

Absorption: GI absorption requires bile acids, fat, lipase, and protein. Aqueous preparations are absorbed more readily than emulsions.

Distribution: Stored primarily in the liver (2-yr supply); small amounts stored in kidneys and lungs. Does not cross the placenta but enters breast milk.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-life: Unknown.

• Instruct patient to take medication as directed. If a dose is missed, it should be omitted, as fat-soluble vitamins are stored in the body for long periods.
• Encourage patient to comply with diet recommendations of health care professional. Explain that the best source of vitamins is a well-balanced diet with foods from the four basic food groups.
• Foods high in vitamin A include liver, fish liver oils, egg yolks, yellow-orange fruits and vegetables, dark green leafy vegetables, whole milk, vitamin A–fortified skim milk, butter, and margarine. Ordinary cooking does not destroy vitamin A, but frozen foods lose 5–10% during storage for 12 mo.
• Patients self-medicating with vitamin supplements should be cautioned not to exceed RDA. The effectiveness of megadoses for treatment of various medical conditions is unproved, and this may cause side effects and toxicity.
• Review symptoms of hypervitaminosis A syndrome (headaches, bulging fontanelles in infants, irritability, yellow-orange discoloration of skin, drying and desquamation of skin and lips, hair loss, anorexia, vomiting, joint and bone pain). Instruct patient to report these symptoms promptly to health care professional.
• Advise patient that mineral oil may interfere with the absorption of fat-soluble vitamins and should not be used concurrently.
• Emphasize the importance of follow-up exams to evaluate progress. Ophthalmologic exams may be required prior to and periodically throughout therapy.

VYE-ta-min A

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