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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: chest pain, peripheral edema

Derm: rash, pruritus

EENT: rhinitis

Endo: hyperglycemia

GI: abdominal cramps, constipation, diarrhea, flatus, heartburn, altered taste, drug-induced hepatitis, dyspepsia, ↑liver enzymes, nausea, pancreatitis

GU: erectile dysfunction

MS: arthralgia, arthritis, immune-mediated necrotizing myopathy, myalgia, myositis, RHABDOMYOLYSIS

Neuro: amnesia, confusion, dizziness, headache, insomnia, memory loss, weakness

Resp: bronchitis

Misc: hypersensitivity reactions

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Pravachol

Action ⬆ ⬇

  • Inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme responsible for catalyzing an early step in the synthesis of cholesterol.
Therapeutic effects:
  • Lowering of total cholesterol and LDL-C and triglycerides. Slightly increases HDL-C.
  • Slows the progression of coronary atherosclerosis with resultant decrease in coronary heart disease-related events.

Classifications ⬆ ⬇

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: hmg coa reductase inhibitors (statins)

Pharmacokinetics ⬆ ⬇

Absorption: Poorly and variably absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Extensively metabolized by the liver, most during first pass; excreted in bile and feces. 20% excreted unchanged by the kidneys.

Half-Life: 1.3–2.7 hr.

Time/Action Profile ⬆ ⬇

(cholesterol-lowering effect)

ROUTEONSETPEAKDURATION
POdays2–4 wkunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

PRA-va-sta-tin

Pill Image

PravastatinSodium_195-8986.jpg

Code ⬆

NDC Code