- PO (Adults ): Pharyngitis/tonsillitis: 250 mg every 12 hr for 10 days; Acute maxillary sinusitis: 500 mg every 12 hr for 14 days or 1000 mg once daily for 14 days as XL tablets; Acute exacerbation of chronic bronchitis: 250–500 mg every 12 hr for 7–14 days or 1000 mg once daily for 7 days as XL tablets; Community-acquired pneumonia: 250 mg every 12 hr for 7–14 days or 1000 mg once daily for 7 days as XL tablets; Skin/skin structure infections: 250 mg every 12 hr for 7–14 days; H. pylori: 500 mg 2–3 times daily with a proton pump inhibitor (lansoprazole or omeprazole) with or without amoxicillin for 10–14 days; Endocarditis prophylaxis: 500 mg 1 hr before procedure; MAC prophylaxis/treatment: 500 mg twice daily, for active infection another antimycobacterial is required.
- PO (Children ≥6 mo): Most infections: 15 mg/kg/day divided every 12 hr for 7–14 days (up to 500 mg/dose for MAC). Endocarditis prophylaxis: 15 mg/kg 1 hr before procedure.
Renal Impairment
- PO (Adults ): CCr <30 mL/min: 250 mg 1–2 times daily, a 500-mg initial dose may be used.
- PO (Children ): CCr <30 mL/min: ↓dose by 50% or double dosing interval.
