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Indications

REMS


Unlabeled Use:
  • Prevention of recurrent vaginal yeast infections.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Oropharyngeal Candidiasis

Renal Impairment

Esophageal Candidiasis

Renal Impairment

Vaginal Candidiasis

Systemic Candidiasis

Renal Impairment

Cryptococcal Meningitis

Renal Impairment

Prevention of Candidiasis after Bone Marrow Transplant

Renal Impairment

US Brand Names

Diflucan

Action

  • Inhibits synthesis of fungal sterols, a necessary component of the cell membrane.
Therapeutic effects:
  • Fungistatic action against susceptible organisms.
  • May be fungicidal in higher concentrations.

Spectrum:

Classifications

Therapeutic Classification: antifungals (systemic)

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed, good penetration into CSF, saliva, sputum, vaginal fluid, skin, eye, and peritoneum.

Metabolism/Excretion: >80% excreted unchanged by the kidneys; <10% metabolized by the liver.

Half-Life: Premature neonates: 46–74 hr; Children: 19–25 hr (PO) and 15–17 hr (IV); Adults: 30 hr ( in renal impairment).

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown2–4 hr24 hr
IVrapidend of infusion24 hr

Patient/Family Teaching

Pronunciation

floo-KON-a-zole

Pill Image

fluconazole_195-8739.jpg

Code

NDC Code