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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: chest pain, QT interval prolongation, TORSADES DE POINTES

Neuro: dizziness, headache

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Tikosyn

Action ⬆ ⬇

  • Blocks cardiac ion channels responsible for transport of potassium.
  • Increases monophasic action potential duration.
  • Increases effective refractory period.
Therapeutic effects:
  • Prevention of recurrent AF/AFl.
  • Conversion of AF/AFl to normal sinus rhythm.

Classifications ⬆ ⬇

Therapeutic Classification: antiarrhythmics (class III)

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (>90%) following oral administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Primarily metabolized in the liver via the CYP3A4 isoenzyme; 80% excreted by kidneys via cationic renal secretion, mostly as unchanged drug; 20% excreted as inactive metabolites.

Half-Life: 10 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POwithin hrs2–3 hr‡12–24 hr

‡Steady state levels are achieved after 2–3 days.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

doe-FET-il-ide

Code ⬆

NDC Code