• Prevention and treatment of postpartum or postabortion hemorrhage caused by uterine atony or subinvolution.

Contraindicated in:

• Hypersensitivity
• Concurrent use of strong CYP3A4 inhibitors
• OB: Should not be used to induce labor
• Lactation: Lactation.

Use Cautiously in:

• Hypertensive or eclamptic patients (more susceptible to hypertensive and arrhythmogenic side effects)
• History of or risk factors for coronary artery disease
• Severe renal impairment
• Severe hepatic impairment
• Sepsis.

Exercise Extreme Caution in:

• OB: Third stage of labor.

CV: arrhythmias, chest pain, heart block, HYPERTENSION, palpitations.

Derm: ↑sweating.

EENT: tinnitus.

GI: nausea, vomiting.

GU: cramps.

Neuro: dizziness, headache, paresthesia, STROKE.

Resp: dyspnea.

Drug-Drug:

• Strong CYP3A4 inhibitors, including erythromycin, clarithromycin, ritonavir, nelfinavir, ketoconazole, itraconazole, or voriconazole, may ↑ levels and ↑ risk of ischemia; concurrent use contraindicated.
• Excessive vasoconstriction may result when used with heavy cigarette smoking (nicotine), other vasopressors, such as dopamine, or beta-blockers.
• Moderate CYP3A4 inhibitors, including nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, or clotrimazole, may ↑ levels and risk of toxicity; use concurrently with caution.
• CYP3A4 inducers, including nevirapine and rifampin, may ↓ levels and effectiveness.
• Anesthetics may ↓ its oxytocic properties
• May ↓ the antianginal effects of nitrates.

Drug-Food:

• Grapefruit juice may ↑ levels and risk of toxicity; use concurrently with caution.

(Generic available)

• Tablets: 0.2 mg;
• Injection: 0.2 mg/mL;

• PO (Adults): 0.2–0.4 mg every 6–12 hr for 2–7 days.
• IM, IV (Adults): 0.2 mg every 2–4 hr for up to 5 doses.

Methergine

• Directly stimulates uterine and vascular smooth muscle.

• Uterine contraction.

Therapeutic Classification: oxytocics

Pharmacologic Classification: ergot alkaloids

Absorption: Well absorbed following oral or IM administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Probably metabolized by the liver.

Half-life: 30–120 min.

(effects on uterine contractions)

• Instruct patient to take medication as directed; do not skip or double up on missed doses. If a dose is missed, omit it and return to regular dose schedule.
• Advise patient that medication may cause menstrual-like cramps.
• Caution patient to avoid smoking, because nicotine constricts blood vessels.
• Instruct patient to notify health care professional if infection develops, as this may cause increased sensitivity to the medication.
• Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.

meth-ill-er-goe-NOE-veen

NDC Code^*

• 0054- West-Ward Pharmaceuticals Corp
  • 0054-0639- Methylergonovine Maleate
    • 0054-0639-03- 7 TABLET in 1 BOTTLE (0054-0639-03)

• 0054- West-Ward Pharmaceuticals Corp
  • 0054-0639- Methylergonovine Maleate
    • 0054-0639-05- 12 TABLET in 1 BOTTLE (0054-0639-05)

• 0054- West-Ward Pharmaceuticals Corp
  • 0054-0639- Methylergonovine Maleate
    • 0054-0639-13- 28 TABLET in 1 BOTTLE (0054-0639-13)

• 0054- West-Ward Pharmaceuticals Corp
  • 0054-0639- Methylergonovine Maleate
    • 0054-0639-25- 100 TABLET in 1 BOTTLE (0054-0639-25)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-3655- Methylergonovine Maleate
    • 0093-3655-22- 12 TABLET in 1 BOTTLE (0093-3655-22)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-3655- Methylergonovine Maleate
    • 0093-3655-28- 28 TABLET in 1 BOTTLE (0093-3655-28)

• 0517- American Regent, Inc.
  • 0517-0740- Methylergonovine Maleate
    • 0517-0740-20- 20 VIAL, SINGLE-DOSE in 1 CARTON (0517-0740-20) > 1 mL in 1 VIAL, SINGLE-DOSE (0517-0740-01)

• 17478- Akorn, Inc.
  • 17478-501- Methylergonovine Maleate
    • 17478-501-01- 10 AMPULE in 1 CARTON (17478-501-01) > 1 mL in 1 AMPULE

• 27437- Lupin Pharma
  • 27437-050- Methergine
    • 27437-050-01- 100 TABLET in 1 BOTTLE (27437-050-01)

• 27437- Lupin Pharma
  • 27437-050- Methergine
    • 27437-050-19- 7 TABLET in 1 BOTTLE (27437-050-19)

• 27437- Lupin Pharma
  • 27437-050- Methergine
    • 27437-050-56- 28 TABLET in 1 BOTTLE (27437-050-56)

• 27437- Lupin Pharma
  • 27437-050- Methergine
    • 27437-050-57- 12 TABLET in 1 BOTTLE (27437-050-57)

• 40032- Novel Laboratories, Inc.
  • 40032-140- Methylergonovine Maleate
    • 40032-140-01- 100 TABLET in 1 BOTTLE (40032-140-01)

• 40032- Novel Laboratories, Inc.
  • 40032-140- Methylergonovine Maleate
    • 40032-140-07- 7 TABLET in 1 BOTTLE (40032-140-07)

• 40032- Novel Laboratories, Inc.
  • 40032-140- Methylergonovine Maleate
    • 40032-140-28- 28 TABLET in 1 BOTTLE (40032-140-28)

• 43386- Lupin Pharmaceuticals,Inc.
  • 43386-140- Methylergonovine Maleate
    • 43386-140-01- 100 TABLET in 1 BOTTLE (43386-140-01)

• 43386- Lupin Pharmaceuticals,Inc.
  • 43386-140- Methylergonovine Maleate
    • 43386-140-07- 7 TABLET in 1 BOTTLE (43386-140-07)

• 43386- Lupin Pharmaceuticals,Inc.
  • 43386-140- Methylergonovine Maleate
    • 43386-140-12- 12 TABLET in 1 BOTTLE (43386-140-12)

• 43386- Lupin Pharmaceuticals,Inc.
  • 43386-140- Methylergonovine Maleate
    • 43386-140-28- 28 TABLET in 1 BOTTLE (43386-140-28)

• 50090- A-S Medication Solutions
  • 50090-4536- METHYLERGONOVINE MALEATE
    • 50090-4536-0- 1 mL in 1 AMPULE (50090-4536-0)

• 51991- Breckenridge Pharmaceutical, Inc.
  • 51991-144- METHYLERGONOVINE MALEATE
    • 51991-144-17- 10 AMPULE in 1 BOX (51991-144-17) > 1 mL in 1 AMPULE

• 60687- American Health Packaging
  • 60687-410- Methylergonovine Maleate
    • 60687-410-94- 20 BLISTER PACK in 1 BOX, UNIT-DOSE (60687-410-94) > 1 TABLET in 1 BLISTER PACK (60687-410-11)

• 63704- Pharmacist Pharmaceutical, LLC
  • 63704-004- METHYLERGONOVINE MALEATE
    • 63704-004-01- 10 AMPULE in 1 BOX (63704-004-01) > 1 mL in 1 AMPULE

• 69238- Amneal Pharmaceuticals NY LLC
  • 69238-1605- Methylergonovine Maleate
    • 69238-1605-2- 12 TABLET in 1 BOTTLE (69238-1605-2)

• 69238- Amneal Pharmaceuticals NY LLC
  • 69238-1605- Methylergonovine Maleate
    • 69238-1605-8- 28 TABLET in 1 BOTTLE (69238-1605-8)