High Alert
Contraindicated in:
Use Cautiously in:
CV: peripheral edema, CARDIAC TAMPONADE, PERICARDIAL EFFUSION
Derm: alopecia, edema, rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP), dermatitis, desquamation, erythema, nail disorders, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
EENT: cystoid macular edema
GI: diarrhea, nausea, stomatitis, vomiting, ASCITES, ENTEROCOLITIS, NEUTROPENIC COLITIS
GU: ↓fertility (males), amenorrhea
Hemat: anemia, leukopenia, thrombocytopenia
Local: injection site reactions
MS: myalgia, arthralgia
Neuro: fatigue, weakness, alcohol intoxication, neurosensory deficits, peripheral neuropathy
Resp: ACUTE RESPIRATORY DISTRESS SYNDROME, bronchospasm, dyspnea, INTERSTITIAL LUNG DISEASE, PULMONARY EDEMA, PULMONARY FIBROSIS
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), MALIGNANCY (INCLUDING LEUKEMIAS, MYELODYSPLASTIC SYNDROME, NON-HODGKIN'S LYMPHOMA, AND RENAL CANCER), tumor lysis syndrome
Drug-drug:
Absorption: IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Half-Life: 116 hr.
NDC Code
