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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Endo: HYPOGLYCEMIA

GI: diarrhea

MS: arthropathy, back pain

Neuro: dizziness

Resp: bronchitis, cough, upper respiratory infection

Misc: flu symptoms

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Starlix

Action ⬆ ⬇

  • Stimulates the release of insulin from pancreatic beta cells by closing potassium channels, which results in the opening of calcium channels in beta cells. This is followed by release of insulin. Requires functioning pancreatic beta cells.
Therapeutic effects:
  • Lowering of blood glucose.

Classifications ⬆ ⬇

Therapeutic Classification: antidiabetics

Pharmacologic Classification: meglitinides

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (73%) following oral administration; absorption is rapid.

Distribution: Unknown.

Protein Binding: 98%.

Metabolism/Excretion: Mostly metabolized by the liver (CYP2C9 [70%] and CYP3A4 [30%]); 16% excreted unchanged in urine.

Half-Life: 1.5 hr.

Time/Action Profile ⬆ ⬇

(effect on blood glucose)

ROUTEONSETPEAKDURATION
POwithin 20 min1 hr4 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

na-TEG-li-nide

Code ⬆

NDC Code