Contraindicated in:
Use Cautiously in:
CV: heart failure.
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, itching, rash.
GI: HEPATOTOXICITY, anorexia, diarrhea, nausea, stomach pain, vomiting, drug-induced hepatitis, smell disturbance, taste disturbance.
Hemat: hemolytic uremic syndrome, neutropenia, pancytopenia, thrombotic thrombocytopenic purpura.
Neuro: depression, headache.
Resp: cough, nasopharyngitis.
Misc: fever.
Drug-Drug:
Drug-Natural Products:
Spectrum:
Absorption: 70–80% absorbed after oral administration.
Distribution: Extensively distributed; penetrates dermis and epidermis; concentrates in stratum corneum, hair, scalp, and nails. Enters breast milk.
Protein Binding: 99%.
Metabolism/Excretion: Extensively metabolized by the liver by CYP1A2, CYP2C9, CYP2C19, and CYP3A4.
Half-life: Plasma — 22 days; longer from skin and nails.
NDC Code*